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General description

Recombinant humanized collagen (type III) is the main component of the extracellular matrix and mainly presented in the form of insoluble fibrin. It is widely presented in animal bone, tendon, sheath muscles, ligaments, fascia, cartilage and skin, and is a extremely important protein in the connective tissue which accounting for 25% to 30% of the total protein of animal body. Its function are supporting organ and protecting the body. It is also the most important protein specie located in cellular matrix. There are many types of collagen; Collagen of bone and skin generally belong to type I collagen; Collagen of cartilage belongs to type II; Type III collagen is located in embryo skin; Collagen of cell basilar membrane belongs to type IV. Collagen has a unique triple helix structure which makes its molecular structure be very stable and make it have low immunogenicity and good biodegradability property. Collagen, as a natural biological resource, has a unique biocompatible and biodegradable property which cannot be matched by any synthetic polymer material today. In addition, it has other features such as high tensile strength, low immunity, bleeding inhibition and promoting cell growth and proliferation. So, it is widely used in clinical medicine, cosmetics, food, chemicals and many other research areas. Composition Collagen is abundant of nutrient. Besides being rich in tryptophan and cysteine, it also ??contains hydroxyproline and pyroglutamatge which is rarely presented in common proteins. 1. In addition to cystine and tryptophan, collagen is rich in 18 kinds of amino acids, including seven kinds of essential amino acids for humans. 2. The content of glycine in collagen accounted for nearly one-third. 3. Collagen contains hydroxylysine and hydroxyproline, which is lacking in other proteins. Figure 1 Composition of collagen proteins